Successful R0 Resection of a Giant 48 cm Retroperitoneal Liposarcoma - Probably One of the Largest Reported Cases Managed in Rajasthan
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Successful R0 Resection of a Giant 48 cm Retroperitoneal Liposarcoma - Probably One of the Largest Reported Cases Managed in Rajasthan

Oncology |by Dr. Anand Mohan| Published on 17/07/2026

Patient: XYZ

Comorbidities: Hypertension (HTN), Diabetes Mellitus (DM), and Coronary Artery Disease (CAD)

Clinical Presentation:

Patient presented with a progressively enlarging abdominal lump for 2 months. Evaluation revealed a massive right retroperitoneal sarcoma measuring 48 × 30 × 20 cm, making it one of the largest reported retroperitoneal sarcomas managed in Rajasthan. The remainder of the metastatic workup and imaging studies were within normal limits.

Procedure Performed:

Right Retroperitoneal Compartmental Resection comprising:

  • En bloc excision of retroperitoneal tumor
  • Right nephrectomy
  • Right hemicolectomy
  • Ileocolic anastomosis (EIA reconstruction)
  • Omentoplasty

Major Surgical and Perioperative Challenges:

  • Giant tumor bulk causing restricted operative access and significant technical complexity.
  • Multiple comorbidities with borderline cardiac and renal reserve, increasing perioperative risk.
  • Significant intraoperative blood loss necessitating blood transfusions.
  • Requirement for prolonged and intensive postoperative ICU management.
  • Multivisceral resection involving the right kidney and colon.
  • Hemodynamic instability for approximately 72 hours secondary to major fluid shifts.
  • High BMI adding to operative and anesthetic challenges.
  • Prolonged operative duration of approximately 8 hours.
  • Compression of the Inferior Vena Cava (IVC) and external iliac vessels resulting in distorted anatomy and technically demanding dissection.
  • Intraoperative hypothermia due to prolonged exposure of a large body surface area.

Outcome:

  • Successful R0 resection of retroperitoneal liposarcoma achieved.
  • Patient remained under close postoperative monitoring with multidisciplinary ICU support.
  • Gradual recovery with stabilization of hemodynamic parameters and organ functions.
  • Discharged on Postoperative Day 8 in a vitally stable condition.
  • No postoperative complications at the time of discharge.
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